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Key Studies & Scientific Reviews Published: January 2005 – March 2005 |
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In This Issue
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Roles For Cell Death In Zinc Deficiency Published in the Journal of Nutrition, this review considers the mechanisms by which nutritional deficiencies of zinc promote cell death and lead to profound impacts on development, growth, immune function, and health. http://www.nutrition.org/cgi/content/abstract/135/3/359 Dietary Intake of Lycopene Is Associated with Reduced Pancreatic Cancer Risk Published in the March edition of the Journal of Nutrition investigated the possible association between dietary carotenoids and pancreatic cancer risk. A 3 year case-control study of 462 histologically confirmed pancreatic cancer cases and 4721 population-based controls in 8 Canadian concluded that a diet high in lycopene content may help reduce pancreatic cancer risk. http://www.nutrition.org/cgi/content/abstract/135/3/592 How Colostrum Helps Build Infants Immune Systems. Review There have been considerable advances in understanding of the diverse mixture of bioactive components in human milk that influence the immune status of infants in recent years. This update briefly reviews immune development in infants and focuses on current knowledge of how both the "classical" immune and the non immune ingredients found in mature human milk promote immune development, facilitate the development of tolerance, and regulate the inflammatory response of infants. http://www.nutrition.org/cgi/content/abstract/135/1/1 Farming changes of the last 1000 years too fast for the Human Genome to adjust? A possible cause of modern disease. Commentary. This commentary, published in February’s edition of the American Journal of Clinical Nutrition looks at the fundamental changes in the human diet over the last 1000 years, and ask the question if whether changes in glycemic load, fatty acid composition, macronutrient composition, micronutrient density, acid-base balance, sodium-potassium ratio, and fibre content may underpin genetic susceptibilities to modern disease http://www.ajcn.org/cgi/content/abstract/81/2/341 Mixed tocopherols rather than α-tocopherol may be responsible for protective assoication of Vitamin E in Alzheimers disease. Previous studies have observed that a high intake of vitamin E from food (tocopherol), but not from supplements (which usually contain http://www.ajcn.org/cgi/content/abstract/81/2/508 Calcium supplementation in Adolescence has long term benefits Short term studies have shown that calcium supplements can help build bone in puberty, but it was not known if these benefits translated into adulthood. This study examined 354 girls over 7 years and found that Calcium supplementation significantly influenced bone density and mass in young females during the pubertal growth spurt. By young adulthood, significant effects remained in tall persons which indicated that the calcium requirement for growth is associated with skeletal size. These results may be important for both primary prevention of osteoporosis and prevention of bone fragility fractures during growth, http://www.ajcn.org/cgi/content/abstract/81/1/175 Dietary Polyphenols and Health: Proceedings of the 1st International Conference on Polyphenols and Health Over the last decade there has been considerable amounts of research on polyphenols or bioflavonoids, and their potent anti-oxidant properties. However, it is becoming clear that the roles that these molecules play in health and their wider benefits are more complex. This group of articles reviews the evidence to date for polyphenols in health interventions, findings and future subjects for research. http://www.ajcn.org/content/vol81/issue1/ High Vitamin C Supplemental Intake Associated with Reduced Coronary Heart Disease Risk This meta-analysis of 9 cohort studies shows a reduced risk of CHD in individuals who took supplemental Vitamin C at doses of 700mg a day or more. However, this reduction in risk was not seen at high dose supplementation with either Vitamin E or carotenoids. However, most supplements of vitamin E used in these studies included α-tocopherol rather than mixed tocopherols. http://www.ajcn.org/cgi/content/abstract/80/6/1508 Autism: - A link to abnormal metabolism of methionine and homcysteine? Researchers from the Department of Pediatrics, University of Arkansas for Medical Sciences have published a study in the American Journal of Nutrition which evaluated the plasma concentrations of metabolites in the methionine transmethylation and transsulfuration pathways in children diagnosed with autism. Compared with controls, they found a metabolic profile that indicates an increased vulnerability to oxidative stress and a decreased capacity for methylation in autistic childeren. These metabolic differences may contribute to the development and clinical manifestation of autism. http://www.ajcn.org/cgi/content/abstract/80/6/1611
Study supports hypothesis For Oral Administration of the Amino Acid L-Arginine for Blood Pressure Reduction This randomised pilot, placebo controlled, cross over study provides support for the hypothesis that L-arginine administered orally can reduce blood pressure. The showed that changes in plasma L-arginine were inversely correlated with the change in plasma homocysteine and did not affect total peripheral resistance, plasma insulin, plasma glucose, C-reactive protein, or lipids. http://www.nutrition.org/cgi/content/abstract/135/2/212 Supplementing with Omega 3 could improve cognitive function in old age This observational study followed up subjects between 2000 – 2001 who had their IQ assessed in 1947. Following adjustments for IQ, and correlating the omega 3 content of erythrocytes the study found that supplement use and erythrocyte n–3 content are associated with better cognitive aging. If associations with n–3 content are causal, optimization of n–3 and n–6 fatty acid intakes could improve retention of cognitive function in old age.
http://www.ajcn.org/cgi/content/abstract/80/6/1650 Vitamin D Insufficiency: A Significant Risk Factor in Chronic Diseases and Potential Disease-Specific Biomarkers of Vitamin D Sufficiency. Symposium. The growing problem of Vitamin D insufficiency on a global basis is highlighted in these symposia reports, and that these deficiencies are linked to increased risks of osteoporosis, diabetes, cancer, and autoimmune disorders. Recent studies demonstrate safety and efficacy of community-based vitamin D supplementation trials and food staple fortification as an alternative to increased sun exposure, and the symposia discuss the need for increased RDA guidance amounts to be set, strategies for increasing consumption as well as discussing the role of Vitamin D in type 1 diabetes prevention, prostate and colon cancer prevention. http://www.nutrition.org/content/vol135/issue2/
Symposium. Vitamin E & Heart Disease Debate Epidemiologic studies suggest benefits for high intakes of http://www.nutrition.org/cgi/content/abstract/135/2/348
Study Indicates Significant Reduction In Prostate Cancer Risk A new study published in the Journal of the National Cancer Institute showed that high blood levels of either alpha-tocopherol or gamma-tocopherol, both forms of vitamin E, appeared to halve the risk of prostate cancer in a new analysis of the ATBC trial. Original findings from the ATBC study, which included nearly 30,000 Finnish men, showed that daily supplements of alpha-tocopherol (50mg) reduced the risk of prostate cancer by 32 per cent. In a new analysis, Professor Virtamo, based at the National Public Health Institute in Helsinki, Finland, and colleagues from the National Cancer Institute in Bethesda, Maryland and the Fred Hutchinson Cancer Research Center looked at the impact of circulating vitamin E levels on 100 individuals with prostate cancer and 200 cancer-free controls participating in the trial. Men with the highest levels of alpha-tocopherol in their blood at baseline were 51 per cent less likely to develop prostate cancer than those with the lowest levels. Similarly, men with the highest levels of gamma-tocopherol were 43 per cent less likely to develop the disease compared with men with the lowest levels. Further research is required to confirm any protective effects from supplementation. Journal of the National Cancer Institute (vol 97, no 5, pp396-399).
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